How Does a Salamander Graft Work?

In David M. Gardner's Lab at University of California at Irvine, they work with salamanders to see what happens when these amphibians lose a limb. Under anesthesia, the scientists removed an Axolotl leg and the above gif is a time lapse of the salamander body's response.

Figure A below shows the process a salamander uses to regenerate and amputated limb.

Figure B is a model of cell division and differentiation.

References:

Joven, A., Elewa, A., & Simon, A. (2019). Model systems for regeneration: salamanders. Development, 146.

Nature Publishing Group. (n.d.). Cell Differentiation and Tissue. Nature news. Retrieved December 8, 2022, from https://www.nature.com/scitable/topicpage/cell-differentiation-and-tissue-14046412/

1. Growing a new limb

Drag the answers below into the grey placeholders above

gives the salamander an survival advantage

increases the chances of reproduction

is disadvantgeous to the salamander

2. Mitosis is involved in this process by allowing a cell to into cell(s).

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parent

differentiated

combine

daughter

reproductive

unique

stem

divide

3. The genetic information passed from one cell in the Axolotl arm to new cells is:

Different from the cells it came from, based on the tissue type it becomes.
Unique from the cell it came from and all cells it might divide into in the future.
Identical to the cells it came from.
Similar, but not identical

4. Differentiation and mitosis are different because:

Differentiation involves making cells with different genetic profiles than the parent cell.
Daughter cells produced through both have the same genes as the parent cells, but differentiated cells have different genes expressed.
Mitosis involves making cells with different genetic profiles than the parent cell, but differentiation produces genetically identical daughter cells.
Mitosis creates stem cells with identical genes, but the process differentiation never creates stem cells that can become multiple types of cells.

5. What are 2 limitations of the model, "Stages of Axolotl limb regeneration?"

6. Cite 2 pieces of evidence that cell differentiation occurring in the limb regeneration.

7. How is the mitosis that occurs at the beginning of the regeneration different than the mitosis occurring at the end?

8. Draw a model in the space below to show how mitosis and differentiation are used to regenerate the arm of the Axolotl.

Color

Width

9. Explain how your model shows how mitosis and differentiation are used to regenerate the arm of the Axolotl.

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How Does a Salamander Graft Work?

1. Growing a new limb

Drag the answers below into the grey placeholders above

2. Mitosis is involved in this process by allowing a cell to into cell(s).

Drag the answers below into the grey placeholders above

3. The genetic information passed from one cell in the Axolotl arm to new cells is:

4. Differentiation and mitosis are different because:

5. What are 2 limitations of the model, "Stages of Axolotl limb regeneration?"

6. Cite 2 pieces of evidence that cell differentiation occurring in the limb regeneration.

7. How is the mitosis that occurs at the beginning of the regeneration different than the mitosis occurring at the end?

8. Draw a model in the space below to show how mitosis and differentiation are used to regenerate the arm of the Axolotl.

9. Explain how your model shows how mitosis and differentiation are used to regenerate the arm of the Axolotl.

Get Started with InnerOrbit

LS1.B: Growth and Development of Organisms

HS-LS1-4

HS-LS1-4

LS1.B: Growth and Development of Organisms

LS1.B: Growth and Development of Organisms

HS-LS1-4

LS1.B: Growth and Development of Organisms

HS-LS1-4

HS-LS1-4

Developing and Using Models

Systems and System Models

HS-LS1-4

Systems and System Models

Developing and Using Models

LS1.B: Growth and Development of Organisms

HS-LS1-4

LS1.B: Growth and Development of Organisms

Developing and Using Models

LS1.B: Growth and Development of Organisms

Developing and Using Models

Systems and System Models

HS-LS1-4

HS-LS1-4

Systems and System Models

Developing and Using Models

LS1.B: Growth and Development of Organisms

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